The most common contemporary use of “Bufo” is in reference to Bufo alvarius and its psychoactive secretions, but the term can have other meanings depending on the context.

  1. Bufo (Genus): In biological classification, Bufo is a genus of toads in the family Bufonidae. These toads are commonly known for their dry, warty skin and often terrestrial habits. They are found in various regions around the world, including North America, Central America, South America, and parts of Europe and Asia. Some well-known species include the common toad (Bufo bufo) and the American toad (Bufo americanus).
  2. Bufo Alvarius (Colorado River Toad): This specific species of toad, Bufo alvarius, is also known as the Colorado River toad or the Sonoran Desert toad. It is notable for its secretion of a substance called 5-MeO-DMT (5-methoxy-dimethyltryptamine) from its skin and glands. This substance has psychedelic properties and has been used in traditional practices by indigenous peoples. It has also gained attention in contemporary alternative and psychedelic communities.