Grandmother Ayahuasca is a term used in some Indigenous Amazonian cultures and spiritual practices to personify the plant medicine ayahuasca, which is made from the combination of the Banisteriopsis caapi vine and other plants, commonly including the Psychotria viridis leaf. The term “Grandmother” conveys a sense of reverence, wisdom, and nurturing associated with the plant medicine. Here’s a detailed definition: In summary, “Grandmother Ayahuasca” is a term that personifies the ayahuasca plant medicine, reflecting its role as a wise and nurturing guide in spiritual and healing practices. This personification underscores the reverence with which the plant is held in Indigenous Amazonian cultures and its significance in ceremonial contexts.